Title : Nicotine induces multi-site phosphorylation of Bad in association with suppression of apoptosis.

Pub. Date : 2004 May 28

PMID : 15037618






3 Functional Relationships(s)
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1 Here we report that nicotine potently induces Bad phosphorylation at Ser112, Ser136, and Ser155 in a mechanism involving activation of MAPKs ERK1/2, PI3K/AKT, and PKA in human lung cancer cells. Nicotine mitogen-activated protein kinase 3 Homo sapiens
2 The fact that beta-adrenergic receptor inhibitor (propranolol) blocks nicotine-induced activation of ERK1/2, AKT, PKA, Bad phosphorylation, and cell survival suggests that nicotine-induced Bad phosphorylation may occur through the upstream beta-adrenergic receptors. Nicotine mitogen-activated protein kinase 3 Homo sapiens
3 The fact that beta-adrenergic receptor inhibitor (propranolol) blocks nicotine-induced activation of ERK1/2, AKT, PKA, Bad phosphorylation, and cell survival suggests that nicotine-induced Bad phosphorylation may occur through the upstream beta-adrenergic receptors. Nicotine mitogen-activated protein kinase 3 Homo sapiens