Title : Glycine 154 of the equilibrative nucleoside transporter, hENT1, is important for nucleoside transport and for conferring sensitivity to the inhibitors nitrobenzylthioinosine, dipyridamole, and dilazep.

Pub. Date : 2004 Feb 1

PMID : 15037197






4 Functional Relationships(s)
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1 Glycine 154 of the equilibrative nucleoside transporter, hENT1, is important for nucleoside transport and for conferring sensitivity to the inhibitors nitrobenzylthioinosine, dipyridamole, and dilazep. Glycine solute carrier family 29 member 1 (Augustine blood group) Homo sapiens
2 This difference in inhibition potency is substantially dependent on the difference in amino acid at position 154 in hENT1 (glycine) and hENT2 (serine). Glycine solute carrier family 29 member 1 (Augustine blood group) Homo sapiens
3 Our results, using a yeast expression system, demonstrate that substituting glycine 154 of hENT1 with serine of hENT2 converts hENT1 to a transporter that exhibits partial characteristics of hENT2. Glycine solute carrier family 29 member 1 (Augustine blood group) Homo sapiens
4 Our results, using a yeast expression system, demonstrate that substituting glycine 154 of hENT1 with serine of hENT2 converts hENT1 to a transporter that exhibits partial characteristics of hENT2. Glycine solute carrier family 29 member 1 (Augustine blood group) Homo sapiens