Title : Lysophosphatidic acid induces chemotaxis, oxygen radical production, CD11b up-regulation, Ca2+ mobilization, and actin reorganization in human eosinophils via pertussis toxin-sensitive G proteins.

Pub. Date : 2004 Apr 1

PMID : 15034064






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Cell responses elicited by LPA were inhibited by pertussis toxin indicating that in eosinophils the LPA receptor(s), presumably EDG-2 and/or EDG-7, are coupled to G(i/o) proteins. lysophosphatidic acid lysophosphatidic acid receptor 1 Homo sapiens
2 Moreover, LPA-induced activation of eosinophils could be completely blocked by the EDG-2/EDG-7 antagonist diacylglycerol pyrophosphate. lysophosphatidic acid lysophosphatidic acid receptor 1 Homo sapiens