Title : Molecular mechanisms of impaired endothelial function associated with insulin resistance.

Pub. Date : 2004 Mar

PMID : 15032648






2 Functional Relationships(s)
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1 Experimental evidences suggest that (6R)-5,6,7,8-tetrahydrobiopterin (BH(4)), the natural and essential cofactor of NO synthases (NOS), plays a crucial role not only in increasing the rate of NO generation by NOS but also in controlling the formation of superoxide anion (O(2)(-)) in the endothelial cells. Superoxides nitric oxide synthase 2 Homo sapiens
2 Experimental evidences suggest that (6R)-5,6,7,8-tetrahydrobiopterin (BH(4)), the natural and essential cofactor of NO synthases (NOS), plays a crucial role not only in increasing the rate of NO generation by NOS but also in controlling the formation of superoxide anion (O(2)(-)) in the endothelial cells. Superoxides nitric oxide synthase 2 Homo sapiens