Title : Inactivation of purified human recombinant monoamine oxidases A and B by rasagiline and its analogues.

Pub. Date : 2004 Mar 25

PMID : 15027867






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Rasagiline has the highest specificity for MAO B, as demonstrated by a 100-fold higher inhibition potency (k(inact)/K(i)) compared to MAO A, with the remaining compounds exhibiting lower isozyme specificities. rasagiline monoamine oxidase B Homo sapiens
2 MAO B and MAO A are more selective for the R-enantiomer (rasagiline) compared to the S-enantiomer (S-PAI) by 2500-fold and 17-fold, respectively. rasagiline monoamine oxidase B Homo sapiens
3 Differences in UV/vis and CD spectral data of the complexes of the studied compounds with both MAO A and MAO B are interpreted in light of crystallographic data of complexes of MAO B with rasagiline and its analogues (Binda, C.; et al. rasagiline monoamine oxidase B Homo sapiens
4 Differences in UV/vis and CD spectral data of the complexes of the studied compounds with both MAO A and MAO B are interpreted in light of crystallographic data of complexes of MAO B with rasagiline and its analogues (Binda, C.; et al. rasagiline monoamine oxidase B Homo sapiens