Pub. Date : 2004 Mar 23
PMID : 15023064
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Is aromaticity essential for trapping the catalytic histidine 447 in human acetylcholinesterase? | Histidine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 2 | Replacement of both the acyl pocket residue Phe295 as well as residue Phe338, adjacent to the catalytic His447 in human acetylcholinesterase (HuAChE), resulted in a 680-fold decline in catalytic activity due to conformational destabilization of the histidine side chain [Barak et al. | Histidine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |