Pub. Date : 2004 Mar 4
PMID : 15001986
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Enhanced sensitivity to irinotecan by Cdk1 inhibition in the p53-deficient HT29 human colon cancer cell line. | Irinotecan | tumor protein p53 | Homo sapiens |
| 2 | Since the DNA-damage checkpoint depends on p53 activation, the status of p53 might critically influence the response to CPT-11. | Irinotecan | tumor protein p53 | Homo sapiens |
| 3 | Since the DNA-damage checkpoint depends on p53 activation, the status of p53 might critically influence the response to CPT-11. | Irinotecan | tumor protein p53 | Homo sapiens |
| 4 | Activated wt-p53 increased apoptosis and enhanced sensitivity to CPT-11. | Irinotecan | tumor protein p53 | Homo sapiens |
| 5 | We demonstrate a gain of sensitivity to CPT-11 in a p53-mutated colon cancer model either by restoring wild-type p53 function or by sequential treatment with cdk-Is. | Irinotecan | tumor protein p53 | Homo sapiens |
| 6 | We demonstrate a gain of sensitivity to CPT-11 in a p53-mutated colon cancer model either by restoring wild-type p53 function or by sequential treatment with cdk-Is. | Irinotecan | tumor protein p53 | Homo sapiens |