Title : Antinociceptive effects of peripheral benzodiazepine receptors.

Pub. Date : 2004 Apr

PMID : 15001819






1 Functional Relationships(s)
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1 Pretreatment of mice with Ro5-4864 or PK11195 inhibited the first- and second-phase responses in the formalin test and this effect was significantly reversed by aminoglutethimide, an inhibitor of pregnenolone synthesis, suggesting that the antinociceptive effect of the peripheral-type benzodiazepine receptor ligands is dependent on steroid formation. Pregnenolone translocator protein Mus musculus