Pub. Date : 2004 Mar
PMID : 14998432
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tizanidine is mainly metabolized by cytochrome p450 1A2 in vitro. | tizanidine | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |
| 2 | Recombinant CYP1A2 metabolized tizanidine to a substantial degree (35% in 45 min), but other recombinant CYPs had little metabolic capacity for the drug. | tizanidine | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |
| 3 | CONCLUSIONS: CYP1A2 is primarily responsible for the metabolism of tizanidine. | tizanidine | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |