Pub. Date : 2004 Apr
PMID : 14996553
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Trichloroethanol enhances the activity of recombinant human TREK-1 and TRAAK channels. | 2,2,2-trichloroethanol | potassium two pore domain channel subfamily K member 4 | Homo sapiens |
| 2 | We have investigated the ability of 2,2,2-trichloroethanol (an active metabolite of the general anesthetic chloral hydrate (CH)) to modulate the activity of hTREK-1 and hTRAAK channels expressed heterologously in Chinese hamster ovary cells by using whole-cell patch-clamp recording. | 2,2,2-trichloroethanol | potassium two pore domain channel subfamily K member 4 | Homo sapiens |
| 3 | Trichloroethanol potentiated hTREK-1 and hTRAAK channel activity in a reversible, concentration-dependent manner. | 2,2,2-trichloroethanol | potassium two pore domain channel subfamily K member 4 | Homo sapiens |
| 4 | Our findings identify TREK-1 and TRAAK channels as molecular targets for trichloroethanol and suggest that activation of these channels might contribute to the CNS depressant effects of CH. | 2,2,2-trichloroethanol | potassium two pore domain channel subfamily K member 4 | Homo sapiens |