Title : Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor.

Pub. Date : 2004 Mar

PMID : 14993293






4 Functional Relationships(s)
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1 Here, we show that the related kinase Arg is activated downstream of PDGFRs in a manner dependent on Src family kinases and phospholipase C gamma1 (PLC-gamma1)-mediated phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis, as we showed previously for c-Abl. Phosphatidylinositol 4,5-Diphosphate phospholipase C gamma 1 Homo sapiens
2 Here, we show that the related kinase Arg is activated downstream of PDGFRs in a manner dependent on Src family kinases and phospholipase C gamma1 (PLC-gamma1)-mediated phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis, as we showed previously for c-Abl. Phosphatidylinositol 4,5-Diphosphate phospholipase C gamma 1 Homo sapiens
3 Here, we show that the related kinase Arg is activated downstream of PDGFRs in a manner dependent on Src family kinases and phospholipase C gamma1 (PLC-gamma1)-mediated phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis, as we showed previously for c-Abl. Phosphatidylinositol 4,5-Diphosphate phospholipase C gamma 1 Homo sapiens
4 Here, we show that the related kinase Arg is activated downstream of PDGFRs in a manner dependent on Src family kinases and phospholipase C gamma1 (PLC-gamma1)-mediated phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis, as we showed previously for c-Abl. Phosphatidylinositol 4,5-Diphosphate phospholipase C gamma 1 Homo sapiens