Title : Treatment of epigallocatechin-3-gallate inhibits matrix metalloproteinases-2 and -9 via inhibition of activation of mitogen-activated protein kinases, c-jun and NF-kappaB in human prostate carcinoma DU-145 cells.

Pub. Date : 2004 Apr 1

PMID : 14991864






3 Functional Relationships(s)
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1 RESULTS: Treatment of EGCG to DU-145 cells resulted in dose-dependent inhibition of FCM-induced pro and active both forms of MMP-2 and MMP-9 concomitant with marked inhibition of phosphorylation of ERK1/2 and p38. epigallocatechin gallate mitogen-activated protein kinase 1 Homo sapiens
2 In identical conditions, treatment of EGCG or inhibitors of MEK or p38 to DU-145 cells inhibited FCM-induced phosphorylation of ERK1/2 and/or p38 concomitant reduction in MMP-2 and -9. epigallocatechin gallate mitogen-activated protein kinase 1 Homo sapiens
3 CONCLUSIONS: The inhibition of MMP-2 and MMP-9 in DU145 cells by EGCG is mediated via inhibition of phosphorylation of ERK1/2 and p38 pathways, and inhibition of activation of transcription factors c-jun and NF-kappaB. epigallocatechin gallate mitogen-activated protein kinase 1 Homo sapiens