Pub. Date : 2004 Mar
PMID : 14982862
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mice deficient in the plasminogen activator inhibitor-1 gene (PAI-1-/- mice) are relatively protected from developing pulmonary fibrosis from bleomycin administration. | Bleomycin | serine (or cysteine) peptidase inhibitor, clade E, member 1 | Mus musculus |
| 2 | Mice deficient in the plasminogen activator inhibitor-1 gene (PAI-1-/- mice) are relatively protected from developing pulmonary fibrosis from bleomycin administration. | Bleomycin | serine (or cysteine) peptidase inhibitor, clade E, member 1 | Mus musculus |
| 3 | Conversely, intratracheal instillation of urokinase into bleomycin-injured PAI-1+/+ mice to activate plasminogen caused a significant increase in HGF within bronchoalveolar lavage and caused less collagen accumulation in the lungs. | Bleomycin | serine (or cysteine) peptidase inhibitor, clade E, member 1 | Mus musculus |
| 4 | Administration of an anti-HGF neutralizing antibody markedly increased collagen accumulation in the lungs of bleomycin-injured PAI-1-/- mice. | Bleomycin | serine (or cysteine) peptidase inhibitor, clade E, member 1 | Mus musculus |