Title : The plasminogen activation system reduces fibrosis in the lung by a hepatocyte growth factor-dependent mechanism.

Pub. Date : 2004 Mar

PMID : 14982862






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Following bleomycin administration, we found that HGF protein levels were higher in bronchoalveolar lavage fluid from PAI-1-/- mice compared to wild-type (PAI-1+/+) mice. Bleomycin hepatocyte growth factor Mus musculus
2 Conversely, intratracheal instillation of urokinase into bleomycin-injured PAI-1+/+ mice to activate plasminogen caused a significant increase in HGF within bronchoalveolar lavage and caused less collagen accumulation in the lungs. Bleomycin hepatocyte growth factor Mus musculus
3 Administration of an anti-HGF neutralizing antibody markedly increased collagen accumulation in the lungs of bleomycin-injured PAI-1-/- mice. Bleomycin hepatocyte growth factor Mus musculus