Title : The transcriptional control of TGF-beta in human osteoblast-like cells is distinct from that of IL-1 beta.

Pub. Date : 1992 May

PMID : 1498252






3 Functional Relationships(s)
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1 Treatment of the cells with the systemic hormones 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] (10(-8) M) and parathyroid hormone (10(-7) M) induced an increase in TGF-beta mRNA but failed to stimulate the production of IL-1-beta mRNA. Calcitriol transforming growth factor beta 1 Homo sapiens
2 Treatment of the cells with the systemic hormones 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] (10(-8) M) and parathyroid hormone (10(-7) M) induced an increase in TGF-beta mRNA but failed to stimulate the production of IL-1-beta mRNA. Calcitriol transforming growth factor beta 1 Homo sapiens
3 However, when the stimulating agent 1,25-(OH)2D3 was added in conjunction with hydrocortisone the mRNA expression of TGF-beta mRNA returned to 70% of the stimulated level. Calcitriol transforming growth factor beta 1 Homo sapiens