Pub. Date : 2004 Mar
PMID : 14981131
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the present study, we investigated whether PGE2 regulated interleukin (IL)-1beta-induced matrix metalloproteinase (MMP)-3 production in human gingival fibroblasts (HGF) derived from periodontally healthy subjects and diseased patients. | Dinoprostone | matrix metallopeptidase 3 | Homo sapiens |
| 2 | In HGF from healthy gingiva, PGE2 down-regulated IL-1beta-induced MMP-3 production, whereas in HGF from periodontitis patients, PGE2 enhanced it. | Dinoprostone | matrix metallopeptidase 3 | Homo sapiens |
| 3 | Analysis of these data suggests that, in HGF from healthy tissue, IL-1beta-induced MMP-3 production is down-regulated by PGE2 via EP2 and EP4 receptors, whereas in cells from periodontally diseased tissue, IL-1beta-induced MMP-3 production is up-regulated via EP1 receptors. | Dinoprostone | matrix metallopeptidase 3 | Homo sapiens |
| 4 | Different regulation of IL-1beta-induced MMP-3 production by PGE2 between healthy and periodontally diseased tissues may be involved in the pathogenesis of periodontal disease. | Dinoprostone | matrix metallopeptidase 3 | Homo sapiens |