Title : Regulation of Ras-MAPK pathway mitogenic activity by restricting nuclear entry of activated MAPK in endoderm differentiation of embryonic carcinoma and stem cells.

Pub. Date : 2004 Mar 1

PMID : 14981092






1 Functional Relationships(s)
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1 An intact actin and microtubule cytoskeleton appears to be required for the restriction of MAPK nuclear entry induced by retinoic acid treatment because the cytoskeletal disrupting agents nocodazole, colchicine, and cytochalasin D are able to revert the suppression of c-Fos expression. Tretinoin Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens