Pub. Date : 2004 Jan
PMID : 14971663
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Vanadate activated Akt and promoted S phase entry. | Vanadates | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Furthermore, vanadate increased Akt kinase activity and caused its phosphorylation at Ser473 and Thr308. | Vanadates | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Inhibition of Akt by either inhibitors or transfected cells with dominant negative kinase mutant or dominant negative phosphorylation mutant decreased the percentage of the cells at the S phase induced by vanadate, and reduced both cyclin E and E2F1 expression and phosphorylation of pRb. | Vanadates | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | The present study indicates that Akt plays an essential role in vanadate-induced increase in cell number at S phase and transition from G1 to S phase through E2F-pRb pathway. | Vanadates | AKT serine/threonine kinase 1 | Homo sapiens |