Pub. Date : 2004 Jan
PMID : 14971644
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Arsenite induces HIF-1alpha and VEGF through PI3K, Akt and reactive oxygen species in DU145 human prostate carcinoma cells. | arsenite | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 2 | In this study, we investigated whether arsenite induces expression of hypoxia-inducible factor 1 (HIF-1). | arsenite | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 3 | In this study, we investigated whether arsenite induces expression of hypoxia-inducible factor 1 (HIF-1). | arsenite | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 4 | Here we demonstrate that arsenite induces the expression of HIF-1alpha but not HIF-1beta subunit in DU145 human prostate carcinoma cells. | arsenite | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 5 | Arsenite also increases the expression of VEGF through the induction of HIF-1. | arsenite | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 6 | We also found that arsenite activates PI3K and Akt that are required for arsenite-induced expression of HIF-1alpha and VEGF. | arsenite | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 7 | We also found that arsenite activates PI3K and Akt that are required for arsenite-induced expression of HIF-1alpha and VEGF. | arsenite | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 8 | The induction of HIF-1 and VEGF by arsenite can not be inhibited by MAP kinase inhibitors. | arsenite | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 9 | These data indicate that the arsenite-induced activation of PI3K/Akt signaling and the expression of HIF-1 and VEGF through the generation of ROS could be an important mechanism in the arsenite-induced carcinogenesis. | arsenite | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 10 | These data indicate that the arsenite-induced activation of PI3K/Akt signaling and the expression of HIF-1 and VEGF through the generation of ROS could be an important mechanism in the arsenite-induced carcinogenesis. | arsenite | hypoxia inducible factor 1 subunit alpha | Homo sapiens |