Title : Molecular modeling of CPT-11 metabolism by carboxylesterases (CEs): use of pnb CE as a model.

Pub. Date : 2004 Feb 24

PMID : 14967028






4 Functional Relationships(s)
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1 Molecular modeling of CPT-11 metabolism by carboxylesterases (CEs): use of pnb CE as a model. Irinotecan carboxylesterase 1 Homo sapiens
2 CPT-11 is a prodrug that is converted in vivo to the topoisomerase I poison SN-38 by carboxylesterases (CEs). Irinotecan carboxylesterase 1 Homo sapiens
3 CPT-11 is a prodrug that is converted in vivo to the topoisomerase I poison SN-38 by carboxylesterases (CEs). Irinotecan carboxylesterase 1 Homo sapiens
4 Despite extensive sequence homology, however, the human homologues of this protein, hCE1 and hiCE, metabolize CPT-11 with significantly lower efficiencies. Irinotecan carboxylesterase 1 Homo sapiens