Pub. Date : 2004 Feb 24
PMID : 14967028
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Molecular modeling of CPT-11 metabolism by carboxylesterases (CEs): use of pnb CE as a model. | Irinotecan | carboxylesterase 1 | Homo sapiens |
| 2 | CPT-11 is a prodrug that is converted in vivo to the topoisomerase I poison SN-38 by carboxylesterases (CEs). | Irinotecan | carboxylesterase 1 | Homo sapiens |
| 3 | CPT-11 is a prodrug that is converted in vivo to the topoisomerase I poison SN-38 by carboxylesterases (CEs). | Irinotecan | carboxylesterase 1 | Homo sapiens |
| 4 | Despite extensive sequence homology, however, the human homologues of this protein, hCE1 and hiCE, metabolize CPT-11 with significantly lower efficiencies. | Irinotecan | carboxylesterase 1 | Homo sapiens |