Title : Striatal cells from mutant huntingtin knock-in mice are selectively vulnerable to mitochondrial complex II inhibitor-induced cell death through a non-apoptotic pathway.

Pub. Date : 2004 Apr 1

PMID : 14962977






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 These data show that mutant htt specifically increases cell vulnerability to mitochondrial complex II inhibition and further switched the type of cell death induced by complex II inhibition from apoptosis to a non-apoptotic form, caused by mitochondrial membrane depolarization, probably initiated by mitochondrial calcium overload and subsequent PTP opening. Calcium huntingtin Mus musculus