Title : Mapping of catalytically important residues in the rat L-histidine decarboxylase enzyme using bioinformatic and site-directed mutagenesis approaches.

Pub. Date : 2004 Apr 15

PMID : 14961766






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 HDC (L-histidine decarboxylase), the enzyme responsible for the catalytic production of histamine from L-histidine, belongs to an evolutionarily conserved family of vitamin B6-dependent enzymes known as the group II decarboxylases. Histamine histidine decarboxylase Homo sapiens
2 HDC (L-histidine decarboxylase), the enzyme responsible for the catalytic production of histamine from L-histidine, belongs to an evolutionarily conserved family of vitamin B6-dependent enzymes known as the group II decarboxylases. Histamine histidine decarboxylase Homo sapiens
3 This is the most extensive mutagenesis study yet to identify catalytically important residues in a mammalian HDC protein sequence and it provides a number of novel insights into the mechanism of histamine biosynthesis. Histamine histidine decarboxylase Homo sapiens