Title : The two-step conversion of big endothelin 1 to endothelin 1 and degradation of endothelin 1 by subcellular fractions from human polymorphonuclear leukocytes.

Pub. Date : 1992 Aug 1

PMID : 1495979






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The processing of bET to all its metabolites including ET-1 was prevented by the serine protease inhibitor 3,4-dichloroisocoumarin (DCI; 50 microM) or the elastase inhibitor ONO-5046 (100 microM) but not by phenylmethylsulfonyl fluoride (PMSF; 143 microM), another serine protease inhibitor. 3,4-dichloroisocoumarin endothelin 1 Homo sapiens
2 The processing of bET to all its metabolites including ET-1 was prevented by the serine protease inhibitor 3,4-dichloroisocoumarin (DCI; 50 microM) or the elastase inhibitor ONO-5046 (100 microM) but not by phenylmethylsulfonyl fluoride (PMSF; 143 microM), another serine protease inhibitor. 3,4-dichloroisocoumarin endothelin 1 Homo sapiens
3 The generation of ET-1 following this intervention was inhibited by DCI. 3,4-dichloroisocoumarin endothelin 1 Homo sapiens
4 The degradation of ET-1 by PMN microsomes was prevented by DCI, PMSF, or ONO-5046. 3,4-dichloroisocoumarin endothelin 1 Homo sapiens