Title : Stereoisomers of ketoconazole: preparation and biological activity.

Pub. Date : 1992 Jul 24

PMID : 1495014






1 Functional Relationships(s)
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1 These data indicate that the affinity of azoles for cytochrome P-450 enzymes involved in steroid synthesis is highly dependent on the stereochemistry of the entire molecule, whereas binding to drug metabolizing enzymes is a less selective process. Azoles cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus