Pub. Date : 1992
PMID : 1493577
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | [Demonstration of a protector effect of interleukin-1 against hematologic toxicity of azidothymidine (AZT)]. | Zidovudine | interleukin 1 alpha | Homo sapiens |
| 2 | [Demonstration of a protector effect of interleukin-1 against hematologic toxicity of azidothymidine (AZT)]. | Zidovudine | interleukin 1 alpha | Homo sapiens |
| 3 | Data reported here show that recombinant human interleukin-1 alpha (IL-1 alpha), a pleiotropic cytokine, was demonstrated to be efficient to protect normal human as well as murine hematopoietic progenitors (CFU-GM, CFU-GEMM and BFU-E) from the toxic effect of AZT. | Zidovudine | interleukin 1 alpha | Homo sapiens |
| 4 | Data reported here show that recombinant human interleukin-1 alpha (IL-1 alpha), a pleiotropic cytokine, was demonstrated to be efficient to protect normal human as well as murine hematopoietic progenitors (CFU-GM, CFU-GEMM and BFU-E) from the toxic effect of AZT. | Zidovudine | interleukin 1 alpha | Homo sapiens |
| 5 | The results demonstrate that marrow progenitors respond differently to AZT and point out the potential efficacy of IL-1 alpha to enhance the proliferation of hematopoietic stem cells treated with growth factors (IL-3, erythropoietin) and to minimize the hematopoietic toxicity associated with AZT treatment. | Zidovudine | interleukin 1 alpha | Homo sapiens |