Pub. Date : 2004 Feb
PMID : 14769825
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | LPA caused much less phosphorylation of Akt and this was dependent on PLD activity. | lysophosphatidic acid | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Toxin B, which inactivates Rho GTPases, markedly impaired PLD1 activation and phosphorylation of Akt, p70(S6K), and 4E-BP1 induced by LPA but had a minimal or no effect on the actions of PDGF. | lysophosphatidic acid | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | These results support the hypothesis that LPA activates protein translation through the action of PLD1-generated PA on mTOR and the PI3K/Akt pathway whereas PDGF acts through P13K/Akt independent of PLD1. | lysophosphatidic acid | AKT serine/threonine kinase 1 | Homo sapiens |