Title : Common variants in glutamine:fructose-6-phosphate amidotransferase 2 (GFPT2) gene are associated with type 2 diabetes, diabetic nephropathy, and increased GFPT2 mRNA levels.

Pub. Date : 2004 Feb

PMID : 14764791






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Glutamine:fructose-6-phosphate amidotransferase (GFPT), the rate limiting enzyme in hexosamine biosynthesis, is encoded by the unlinked but highly homologous genes GFPT1 and GFPT2. Hexosamines glutamine-fructose-6-phosphate transaminase 2 Homo sapiens
2 We propose that the 3" UTR variant results in increased GFPT2 mRNA levels with resultant increased hexosamine flux. Hexosamines glutamine-fructose-6-phosphate transaminase 2 Homo sapiens