Pub. Date : 2004 Apr 16
PMID : 14764604
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We show that the lipid phosphatase activity of PTEN mediates chemotaxis and that the sharp localization of PI(3,4,5)P3 requires localization of PTEN to the rear of the cell. | phosphoinositide-3,4,5-triphosphate | phosphatase and tensin homolog | Homo sapiens |
| 2 | On the other hand, the localization of PTEN does not depend on its phosphatase activity, the actin cytoskeleton, or the intracellular level of PI(3,4,5)P3, suggesting that events controlling localization are upstream of phosphoinositide signaling. | phosphoinositide-3,4,5-triphosphate | phosphatase and tensin homolog | Homo sapiens |