Pub. Date : 2004 Jan 30
PMID : 14759370
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lysine acetylation of the tumor suppressor protein p53 in response to a wide variety of cellular stress signals is required for its activation as a transcription factor that regulates cell cycle arrest, senescence, or apoptosis. | Lysine | tumor protein p53 | Homo sapiens |
| 2 | Here, we report that the conserved bromo-domain of the transcriptional coactivator CBP (CREB binding protein) binds specifically to p53 at the C-terminal acetylated lysine 382. | Lysine | tumor protein p53 | Homo sapiens |
| 3 | We further present the three-dimensional nuclear magnetic resonance structure of the CBP bromodomain in complex with a lysine 382-acetylated p53 peptide. | Lysine | tumor protein p53 | Homo sapiens |