Title : Protein expression of PDZ-binding kinase is up-regulated in hematologic malignancies and strongly down-regulated during terminal differentiation of HL-60 leukemic cells.

Pub. Date : 2004 Jan-Feb

PMID : 14757441






1 Functional Relationships(s)
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1 Furthermore, when HL-60 myeloid leukemic cells were differentiated with phorbol ester (TPA), PBK/TOPK protein expression was strongly down-regulated by 24 h. Under these same conditions, phosphorylated c-Myc was rapidly down-regulated (by 4 h), while the levels of cyclin D1 and phosphorylated p38 were constant. Tetradecanoylphorbol Acetate MYC proto-oncogene, bHLH transcription factor Homo sapiens