Title : Thermodynamic dissection of the binding energetics of proline-rich peptides to the Abl-SH3 domain: implications for rational ligand design.

Pub. Date : 2004 Feb 13

PMID : 14757063






2 Functional Relationships(s)
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1 We present here a complete thermodynamic analysis of the binding energetics of the p41 proline-rich decapeptide (APSYSPPPPP) to the SH3 domain of the c-Abl oncogene. Proline mitogen-activated protein kinase 1 Homo sapiens
2 The origin of the binding energetics for proline-rich ligands to the Abl-SH3 domain is further investigated by a comparative calorimetric analysis of a set of p41-related ligands. Proline mitogen-activated protein kinase 1 Homo sapiens