Title : Thermodynamic dissection of the binding energetics of proline-rich peptides to the Abl-SH3 domain: implications for rational ligand design.

Pub. Date : 2004 Feb 13

PMID : 14757063






1 Functional Relationships(s)
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1 We present here a complete thermodynamic analysis of the binding energetics of the p41 proline-rich decapeptide (APSYSPPPPP) to the SH3 domain of the c-Abl oncogene. Proline ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens