Title : ERK1/2 and JNKs, but not p38 kinase, are involved in reactive oxygen species-mediated induction of osteopontin gene expression by angiotensin II and interleukin-1beta in adult rat cardiac fibroblasts.

Pub. Date : 2004 Mar

PMID : 14755545






2 Functional Relationships(s)
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Protein Name
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1 PD98059, ERK1/2 pathway inhibitor, and SP600125, JNKs inhibitor, partially inhibited Ang II + IL-1beta-stimulated increases in OPN mRNA. pyrazolanthrone angiotensinogen Rattus norvegicus
2 A combination of PD98059 and SP600125 almost completely inhibited Ang II + IL-1beta-stimulated increases in OPN mRNA. pyrazolanthrone angiotensinogen Rattus norvegicus