Title : ERK1/2 and JNKs, but not p38 kinase, are involved in reactive oxygen species-mediated induction of osteopontin gene expression by angiotensin II and interleukin-1beta in adult rat cardiac fibroblasts.

Pub. Date : 2004 Mar

PMID : 14755545






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Diphenylene iodonium (DPI), inhibitor of NAD(P)H oxidase, and tiron, superoxide scavenger, inhibited Ang II- and Ang II+ IL-1beta-stimulated increases in OPN mRNA. diphenyleneiodonium interleukin 1 beta Rattus norvegicus
2 Diphenylene iodonium (DPI), inhibitor of NAD(P)H oxidase, and tiron, superoxide scavenger, inhibited Ang II- and Ang II+ IL-1beta-stimulated increases in OPN mRNA. diphenyleneiodonium interleukin 1 beta Rattus norvegicus
3 DPI almost completely inhibited Ang II + IL-1beta-stimulated activation of ERK1/2, while partially inhibiting JNKs. diphenyleneiodonium interleukin 1 beta Rattus norvegicus