Pub. Date : 2004 Feb
PMID : 14755345
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross-tolerance. | Nitroglycerin | aldehyde dehydrogenase 2 family member | Rattus norvegicus |
| 2 | Recent studies suggest that mitochondrial aldehyde dehydrogenase (ALDH-2) plays a central role in the process of nitroglycerin (glyceryl trinitrate, GTN) biotransformation in vivo and that its inhibition accounts for mechanism-based tolerance in vitro. | Nitroglycerin | aldehyde dehydrogenase 2 family member | Rattus norvegicus |
| 3 | Recent studies suggest that mitochondrial aldehyde dehydrogenase (ALDH-2) plays a central role in the process of nitroglycerin (glyceryl trinitrate, GTN) biotransformation in vivo and that its inhibition accounts for mechanism-based tolerance in vitro. | Nitroglycerin | aldehyde dehydrogenase 2 family member | Rattus norvegicus |
| 4 | Recent studies suggest that mitochondrial aldehyde dehydrogenase (ALDH-2) plays a central role in the process of nitroglycerin (glyceryl trinitrate, GTN) biotransformation in vivo and that its inhibition accounts for mechanism-based tolerance in vitro. | Nitroglycerin | aldehyde dehydrogenase 2 family member | Rattus norvegicus |
| 5 | Recent studies suggest that mitochondrial aldehyde dehydrogenase (ALDH-2) plays a central role in the process of nitroglycerin (glyceryl trinitrate, GTN) biotransformation in vivo and that its inhibition accounts for mechanism-based tolerance in vitro. | Nitroglycerin | aldehyde dehydrogenase 2 family member | Rattus norvegicus |
| 6 | Recent studies suggest that mitochondrial aldehyde dehydrogenase (ALDH-2) plays a central role in the process of nitroglycerin (glyceryl trinitrate, GTN) biotransformation in vivo and that its inhibition accounts for mechanism-based tolerance in vitro. | Nitroglycerin | aldehyde dehydrogenase 2 family member | Rattus norvegicus |
| 7 | Recent studies suggest that mitochondrial aldehyde dehydrogenase (ALDH-2) plays a central role in the process of nitroglycerin (glyceryl trinitrate, GTN) biotransformation in vivo and that its inhibition accounts for mechanism-based tolerance in vitro. | Nitroglycerin | aldehyde dehydrogenase 2 family member | Rattus norvegicus |
| 8 | The extent to which ALDH-2 contributes to GTN tolerance (impaired relaxation to GTN) and cross-tolerance (impaired endothelium-dependent relaxation) in vivo remain to be elucidated. | Nitroglycerin | aldehyde dehydrogenase 2 family member | Rattus norvegicus |
| 9 | The extent to which ALDH-2 contributes to GTN tolerance (impaired relaxation to GTN) and cross-tolerance (impaired endothelium-dependent relaxation) in vivo remain to be elucidated. | Nitroglycerin | aldehyde dehydrogenase 2 family member | Rattus norvegicus |
| 10 | Further, whereas in control vessels, multiple inhibitors and substrates of ALDH-2 reduced both GTN-stimulation of cGKI and GTN-induced vasodilation, these agents had little effect on tolerant vessels. | Nitroglycerin | aldehyde dehydrogenase 2 family member | Rattus norvegicus |
| 11 | Further, whereas in control vessels, multiple inhibitors and substrates of ALDH-2 reduced both GTN-stimulation of cGKI and GTN-induced vasodilation, these agents had little effect on tolerant vessels. | Nitroglycerin | aldehyde dehydrogenase 2 family member | Rattus norvegicus |