Pub. Date : 2004 Feb 12
PMID : 14746882
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Olanzapine counteracts reduction of brain-derived neurotrophic factor and TrkB receptors in rat hippocampus produced by haloperidol. | Haloperidol | brain-derived neurotrophic factor | Rattus norvegicus |
| 2 | We compared the effect of 45 day chronic exposure of HAL (2 mg/kg per day) to OLZ (10 mg/kg per day) on brain-derived neurotrophic factor (BDNF)) and its high affinity receptor TrkB in rat hippocampus. | Haloperidol | brain-derived neurotrophic factor | Rattus norvegicus |
| 3 | We compared the effect of 45 day chronic exposure of HAL (2 mg/kg per day) to OLZ (10 mg/kg per day) on brain-derived neurotrophic factor (BDNF)) and its high affinity receptor TrkB in rat hippocampus. | Haloperidol | brain-derived neurotrophic factor | Rattus norvegicus |
| 4 | HAL, but not OLZ, significantly reduced the levels of BDNF in hippocampus. | Haloperidol | brain-derived neurotrophic factor | Rattus norvegicus |
| 5 | Furthermore, post-treatment with OLZ markedly restored the HAL treatment associated reductions in both BDNF and TrkB receptors in hippocampus. | Haloperidol | brain-derived neurotrophic factor | Rattus norvegicus |