Title : Cytotoxicity of 5-fluoro-2'-deoxyuridine: requirement for reduced folate cofactors and antagonism by methotrexate.

Pub. Date : 1978 Feb

PMID : 147465






1 Functional Relationships(s)
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1 Likewise, the intracellular amount of 5-fluoro-2"-deoxyuridylate covalently bound to thymidylate synthase in L1210 cells treated with 5-fluoro-2"-deoxyuridine is greatly diminished when cells are depleted of folate cofactors. Folic Acid thymidylate synthase Mus musculus