Title : Development of an in vivo preclinical screen model to estimate absorption and first-pass hepatic extraction of xenobiotics. II. Use of ketoconazole to identify P-glycoprotein/CYP3A-limited bioavailability in the monkey.

Pub. Date : 2004 Feb

PMID : 14744938






1 Functional Relationships(s)
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1 Next, erythromycin and propranolol were explored as positive and negative control substrates for Pgp/CYP3A interactions, respectively. Propranolol ATP binding cassette subfamily B member 1 Homo sapiens