Title : Suppressive effects of FR167653, an inhibitor of p38 mitogen-activated kinase, on calreticulin mRNA expression induced by endoplasmic reticulum stresses.

Pub. Date : 2004 Jan 26

PMID : 14744598






3 Functional Relationships(s)
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1 In this study, FR167653 concentration-dependently inhibited the up-regulation of the calreticulin mRNA level following an endoplasmic reticulum stress induced by thapsigargin in human embryonic kidney 293 (HEK293) cells and rat phechromocytoma PC12 cells. Thapsigargin calreticulin Homo sapiens
2 The compound concentration-dependently suppressed the transactivation of luciferase by thapsigargin in a reporter assay with a calreticulin promoter-luciferase conjugated reporter vector. Thapsigargin calreticulin Homo sapiens
3 SB203580 also significantly suppressed the transactivation of calreticulin by thapsigargin. Thapsigargin calreticulin Homo sapiens