Title : Cooperative dimerization of the POU domain protein Brn-2 on a new motif activates the neuronal promoter of the human aromatic L-amino acid decarboxylase gene.

Pub. Date : 2004 Jan 5

PMID : 14741405






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We now show that both TB and ONF sites participate in the activation of the neuronal promoter by Brn-2. Terbium POU class 3 homeobox 2 Homo sapiens
2 EMSA experiments showed that the recombinant Brn-2 POU domain dimerized on the TB element in a cooperative manner. Terbium POU class 3 homeobox 2 Homo sapiens
3 By site directed mutagenesis of the POU domain of Brn-2, the dimerization interface on the TB element was localized to the hydrophobic pocket of the POU specific domain and the C-terminal part of the POU homeodomain. Terbium POU class 3 homeobox 2 Homo sapiens