Title : Cox-2 is needed but not sufficient for apoptosis induced by Cox-2 selective inhibitors in colon cancer cells.

Pub. Date : 2003 Dec

PMID : 14739610






1 Functional Relationships(s)
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1 To determine that the higher levels of apoptosis in HT29 cells with SC236 >75 microM were related to decreased Cox-2 protein levels, we decreased Cox-2 protein expression in HT29 cells with curcumin (diferuloylmethane) and studied its effect on SC236-induced apoptosis. Curcumin mitochondrially encoded cytochrome c oxidase II Homo sapiens