Pub. Date : 2004 Jan
PMID : 14732356
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Simvastatin suppresses LPS-induced Akt phosphorylation in the human monocyte cell line THP-1. | Simvastatin | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Akt phosphorylation peaked after 15 min of LPS stimulation and was suppressed by pretreatment with simvastatin. | Simvastatin | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | CONCLUSIONS: These data demonstrate that LPS stimulation leads to increased Akt phosphorylation, which can be suppressed with simvastatin pretreatment. | Simvastatin | AKT serine/threonine kinase 1 | Homo sapiens |