Title : N-hydroxy-MeIQx is the major microsomal oxidation product of the dietary carcinogen MeIQx with human liver.

Pub. Date : 1992 Dec

PMID : 1473228






2 Functional Relationships(s)
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1 The specific inhibitor of human CYP1A2, furafylline (5 microM) inhibited the N-hydroxylation of MeIQx by > 90%. 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline cytochrome P450 family 1 subfamily A member 2 Homo sapiens
2 These data show that N-OHMeIQx is both the major oxidation product and the major genotoxic product of MeIQx generated by microsomal fractions of human liver and that the reaction is catalysed almost exclusively by CYP1A2. 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline cytochrome P450 family 1 subfamily A member 2 Homo sapiens