Pub. Date : 2004 Jan 1
PMID : 14732289
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we evaluated the cytoprotective effect of MCGA3, which occurs via heme oxygenase-1 (HO-1) induction in bovine vascular endothelial cells exposed to tert-butylhydroperoxide (tBHP). | tert-Butylhydroperoxide | heme oxygenase 1 | Bos taurus |
| 2 | In this study, we evaluated the cytoprotective effect of MCGA3, which occurs via heme oxygenase-1 (HO-1) induction in bovine vascular endothelial cells exposed to tert-butylhydroperoxide (tBHP). | tert-Butylhydroperoxide | heme oxygenase 1 | Bos taurus |
| 3 | We observed the time- and dose-dependent induction of HO-1 mRNA and protein, which was closely associated with decreased intracellular ROS and necrosis against tBHP. | tert-Butylhydroperoxide | heme oxygenase 1 | Bos taurus |
| 4 | These results suggested that not only ortho-dihydroxyl groups but also aromatic ester and methoxyl ester moieties are necessary for full HO-1 induction and cytoprotection against toxic tBHP-derived ROS. | tert-Butylhydroperoxide | heme oxygenase 1 | Bos taurus |
| 5 | Consequently, the combined action of HO-1 and ferritin may protect cells from toxic tBHP-mediated necrosis. | tert-Butylhydroperoxide | heme oxygenase 1 | Bos taurus |