Title : Effect of cyclooxygenase and NO synthase inhibitors administered centrally on antinociceptive action of acetaminophen (Part II).

Pub. Date : 2003 Nov-Dec

PMID : 14730095






1 Functional Relationships(s)
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1 Indomethacin (IND), an inhibitor preferentially acting on COX-1, as well as nimesulide (NIM) and celecoxib (CECOX), i.e. preferential and selective inhibitor of COX-2, respectively, administered icv almost completely blocked the antinociceptive effect of ACETA in Randall-Selitto method. nimesulide mitochondrially encoded cytochrome c oxidase II Homo sapiens