Pub. Date : 2004 May
PMID : 14729583
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In another study, celecoxib attenuated the DNA binding activity of activator protein 1 (AP-1) through suppression of c-Jun and c-Fos expression in TPA-treated mouse skin. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |
| 2 | In another study, celecoxib attenuated the DNA binding activity of activator protein 1 (AP-1) through suppression of c-Jun and c-Fos expression in TPA-treated mouse skin. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |
| 3 | In another study, celecoxib attenuated the DNA binding activity of activator protein 1 (AP-1) through suppression of c-Jun and c-Fos expression in TPA-treated mouse skin. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |
| 4 | In the same animal model, TPA treatment resulted in rapid activation via phosphorylation of extracellular signal-regulated protein kinase (ERK)1/2 and p38 MAP kinase, which are upstream of AP-1 in mouse skin. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |
| 5 | In order to clarify the roles of p38 and ERK in TPA-induced AP-1 activation, we utilized the pharmacologic inhibitors of these enzymes. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |
| 6 | The p38 inhibitor SB203580 blocked TPA-mediated AP-1 activation, while the MEK1/2 inhibitor U0126 was not inhibitory despite suppression of c-Fos expression in mouse skin. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |