Title : Metabolic activation of 10-aza-substituted benzo[a]pyrene by cytochrome P450 1A2 in human liver microsomes.

Pub. Date : 2004 Feb 14

PMID : 14729370






1 Functional Relationships(s)
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1 With regard to the proposal that BaP may be activated by human CYP1A1, our results suggest that the nitrogen-substitution at position-10 of BaP may cause the CYP enzyme-specificity in metabolic activation to change from CYP1A1 to CYP1A2. Nitrogen cytochrome P450 family 4 subfamily F member 3 Homo sapiens