Title : Inhibition of apolipoprotein B secretion by taurocholate is controlled by the N-terminal end of the protein in rat hepatoma McArdle-RH7777 cells.

Pub. Date : 2003 Dec 30

PMID : 14729072






5 Functional Relationships(s)
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1 Inhibition of apolipoprotein B secretion by taurocholate is controlled by the N-terminal end of the protein in rat hepatoma McArdle-RH7777 cells. Taurocholic Acid apolipoprotein B Rattus norvegicus
2 The doubly transfected cell lines (h-apoB/r-Ntcp) effectively accumulated taurocholic acid (TC). Taurocholic Acid apolipoprotein B Rattus norvegicus
3 The doubly transfected cell lines (h-apoB/r-Ntcp) effectively accumulated taurocholic acid (TC). Taurocholic Acid apolipoprotein B Rattus norvegicus
4 TC incubation decreased the secretion of endogenous rat apoB100 (-50%) and h-apoB18 (-35%), but did not affect secretion of rat apoA-I. Taurocholic Acid apolipoprotein B Rattus norvegicus
5 We conclude that TC does not inhibit apoB secretion by interference with its lipidation, but rather involves a mechanism dependent on the N-terminal end of apoB. Taurocholic Acid apolipoprotein B Rattus norvegicus