Pub. Date : 2004 Mar
PMID : 14720318
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The 5-HT1A/beta-adrenoceptor ligand (+/-)pindolol has been used in clinical trials to enhance the antidepressant effect of selective serotonin (5-HT) reuptake inhibitors (SSRIs). | Pindolol | 5-hydroxytryptamine receptor 1A | Homo sapiens |
| 2 | The accelerating effect of (+/-)pindolol is thought to derive from its blockade of the SSRI-induced, 5-HT1A autoreceptor-mediated inhibition of serotonergic cell firing and 5-HT release. | Pindolol | 5-hydroxytryptamine receptor 1A | Homo sapiens |
| 3 | In these regions, enriched in 5-HT1A receptors, (+/-)pindolol antagonized the stimulation of [35S]GTPgammaS binding induced by 5-HT in a concentration-dependent manner. | Pindolol | 5-hydroxytryptamine receptor 1A | Homo sapiens |
| 4 | This suggests a higher potency of (+/-)pindolol at somatodendritic 5-HT1A receptors compared to post-synaptic 5-HT1A sites. | Pindolol | 5-hydroxytryptamine receptor 1A | Homo sapiens |