Title : Inverse agonist activity of selected ligands of the cysteinyl-leukotriene receptor 1.

Pub. Date : 2004 Apr

PMID : 14718577






1 Functional Relationships(s)
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1 In cells expressing the CysLT(1)R mutant N106A exposed to Montelukast, Zafirlukast, or 3-[[3-[2-(7-chloroquinolin-2-yl)vinyl]phenyl]-(2-dimethylcarbamoylethylsulfanyl)methylsulfanyl] propionic acid (MK571), the basal inositol phosphate production was reduced by 53 +/- 6, 44 +/- 3, and 54 +/- 4%, respectively. verlukast cysteinyl leukotriene receptor 1 Homo sapiens